![]() In IgA, four (e.g., Der f 1) increased, whereas the other four (e.g., Cry j 1) decreased. The medians of aeroallergen-specific IgE levels did not fluctuate, and almost all IgG1 and IgG4 decreased. Fluctuations of Der f 1- and Cry j 1-specific immunoglobulins levels during the two periods were compared to assess the frequency of allergic statuses and clusters of cytokine/chemokine profiles. We examined nineteen kinds of aeroallergen-specific immunoglobulins (IgE, IgG1, IgG4, and IgA) levels in patients at age 6 and age 8. This study used blood samples from children participating in the JECS Pilot Study. However, the clinical background and cytokine/chemokine profiles associated with changes in immunoglobulins during early school-age are poorly understood. ![]() Most wheeze episodes develop before school age, and allergic rhinitis later develops during early elementary school years. All rights reserved.Īllergen-specific immunoglobulins have a crucial role in allergic diseases. By contrast, an atopic antibody response to PR-10 molecules is delayed, strong, and persistent involves both IgG and IgE and is initiated by airborne PR-10.Ĭopyright © 2014 American Academy of Allergy, Asthma & Immunology. The results suggest that children have a default antibody response to PR-10 molecules, which is early, weak, and transient does not involve IgE and is initiated by foodborne PR-10. This atopic IgG response, as well as the IgE response, involved progressively more foodborne PR-10 proteins with frequencies and levels related to their homology with Bet v 1. Among all atopic subjects, the default IgG response at age 1 year was overwhelmed after age 2 years by an "pre-atopic" IgG response, which started with or shortly before the IgE response and was intense and persistent. Among nonatopic subjects, a "default" IgG response was directed mostly against foodborne PR-10, started often before age 2 years, stayed weak, and was mostly transient. Two different patterns of IgG responses to PR-10 molecules were identified. In the present analyses we included 28 children with birch atopy and randomly selected 28 nonatopic children from the 190 children fulfilling the inclusion criteria. Therefore serum IgE antibodies to a panel of 4 airborne and 5 foodborne extracts, as well as to Bet v 1, were measured in singleplex assays, whereas IgG and IgE antibodies to a panel of 3 airborne PR-10 molecules (rBet v 1, rAln g 1, and rCor a 1.0101) and 7 foodborne PR-10 molecules (rCor a 1.0401, rMal d 1, rPru p 1, rGly m 4, rAra h 8, rApi g 1, and rDau c 1) were tested by using a multiplex microarray. Participants were included in the present analysis if they had (1) at least 1 serum sample at each of the 4 age periods or time points (1-3 years, 5-7 years, 10 years, and 13 years) and (2) IgE responses to birch (children with birch atopy) or no IgE response at all to 9 common aeroallergens and food allergens (nonatopic children). Blood samples were collected at the ages of 1, 2, 3, 5, 6, 7, 10, and 13 years. The German Multicentre Allergy Study examined a birth cohort born in 1990. We sought to investigate the role of route and dose of exposure in the evolution of IgG and IgE responses to recombinant PR-10 molecules. Children are exposed to both pollen-derived (inhaled) and food-derived (ingested) PR-10 molecules. Pathogenesis-related group 10 protein (PR-10) molecules are a family of allergenic proteins shared by many pollens (eg, birch and alder) and foods (eg, apple, peach, and soy). ![]() The route and dose of exposure are believed to be relevant factors in the sensitization process. ![]()
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